Colloquium Schedule

EMBL and EMBO Heidelberg, Germany

 

The cytoskeleton drives many essential processes in vivo, but for this, the system of filaments will arrange itself into different overall spatial organizations, e.g., random, branched networks, parallel bundles, antiparallel arrays, etc. A general objective of our research is to understand what makes these architectures adapted to their tasks. In this talk, I will first focus on 2D disorganized actin networks in which the filaments are oriented randomly and connected both by active molecular motors and passive crosslinkers. Systems with these properties have been reconstituted in vitro, and serve as a model of the cortical actomyosin networks that drive morphogenesis in animal tissues, or cytokinesis during cell division. Although the network components and their properties are known, the requirements for contractility are still poorly understood. I will describe a theory that predicts whether an isotropic network would contract, expand, or conserve its dimensions, depending on the properties of the filaments and the elements that connect them. This simple theory encompasses mechanisms of contractions previously proposed and predicts how the contraction rate depends for example on the ratio of motors to crosslinkers.