Colloquium Schedule

Colloquium: Thursday, April 30, 4:10 PM, Lewis Lab 316

Cell-Matrix Interactions in 3D Microtissues: Multiscale Mechanical Models

Vivek Shenoy

Professor, School of Engineering and Applies Sciences
University of Pennsylvania

Much of our understanding of the biological mechanisms that underlie cellular functions, such as migration, differentiation and force sensing has been garnered from studying cells cultured on two-dimensional (2D) substrates. In the recent years there has been intense interest and effort to understand cell mechanics in three-dimensional (3D) cultures, which more closely resemble the in vivo microenvironment. However, a major challenge unique to 3D settings is the dynamic feedback between cells and their surroundings. In many 3D matrices, cells remodel and reorient local extracellular microenvironment, which in turn alters the active mechanics and in many cases, the cell phenotype. Most models for matrices to date do not account for such positive feedback. Such models, validated by experiments, can provide a quantitative framework to study how injury related factors (in pathological conditions such as fibrosis and cancer metastasis) alter extracellular matrix (ECM) mechanics. They can also be used to analyze tissue morphology in complex 3D environments such as during morphogenesis and organogenesis, and guide such processes in engineered 3D tissues. In this talk, I will present discrete network simulations to study how cells remodel matrices and how this remodeling can lead to force transmission over large distances in cells [1]. I will also discuss an active tissue model to quantitatively study the influence of mechanical constraints and matrix stiffness on contractility and stability of micropatterned tissues [2,3].
1. H. Wang, A, Nair, C, S. Chen, R. G. Wells and V. B. Shenoy, Long Range Force Transmission in Fibrous Matrices Enabled by Tension-Driven Alignment of Fibers, BIOPHYSICAL JOURNAL, 107:2592-2603 (2014).
2. A. Nair, B. Baker, B. Trappmann, C. S. Chen, and V.B. Shenoy, Remodeling of Fibrous Extra Cellular Matrices by Contractile Cells: Predictions from Discrete Fiber Network Simulations, BIOPHYSICAL JOURNAL, 107: 1829–1840 (2014).
3. H. Wang, A. A. Svoronos, T. Boudou, M. S. Sakar, J. Y. Schell, J. R. Morgan, C. S. Chen, and V. B. Shenoy, Necking and failure of constrained 3D microtissues induced by cellular tension PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, 110(52): 20923-20928 (2013).

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Physics and Astronomy Colloquia are usually scheduled for Thursdays at 4:10 PM in Lewis Lab room 316. Refreshments and snacks are available in the nearby coffee room at 3:45 PM.


Physics Colloquium Schedule for SPRING 2015

Click on Title below for past or upcoming Announcements (where available), and Speaker name for website.        

January 22Rosi ReedWayne State UniversityThe Connection Between Quantum Chromodynamics and the Quark Gluon Plasma
January 29Marguerite TonjesUniv. of MarylandStudying the Quark-Gluon Plasma at the Large Hadron Collider
February 5Jean PerezUniv. of New HampshireNew Horizons in Solar Wind Turbulence:
Theory, Simulations and Future Observations
February 12Sera CremoniniTexas A & M Univ."Applied" String Theory
February 19Cindy KeelerNiels Bohr InstituteString Theory in the Age of Duality
February 24 (Tuesday)Yelena ProkOld Dominion Univ.Nucleon Spin Structure: New Results from Jefferson Lab
February 26Dean LeeNorth Carolina StateAre the Parameters of the Standard Model Fine-Tuned for Carbon-Based Life?
March 5No ColloquiumAPS March Meeting-
March 12No ColloquiumSpring Break-
March 19Lev MurokhQueens College, CUNYEnergy Conversion in Mitochondria Membranes: Principles of Operations and Ideas for Nanoelectronics
March 26Nader EnghetaU PennOptics at the Extreme
April 2Anand JagotaLehigh Univ.Influence of Surface Tension Deformation of Compliant Solids
April 9Taeyoon KimPurdue Univ.Force Generation and Mechano-Sensing via Actomyosin Contractility
April 16Boris YakobsonRice UniversityFrom Material Substance to Shape to Property
April 23Dmitry SmirnovFlorida State Univ.When High Magnetic Fields Meet Optical Spectroscopy: Probing Electronic Structure and Interaction Effects in Low-Dimensional Semiconductor- and Carbon-Based Structures
April 30Vivek ShenoyU PennCell-Matrix Interactions in 3D Microtissues: Multiscale Mechanical Models
May 7---